Characterization of an outbreak due to CTX-M-15-producing Klebsiella pneumoniae lacking the blaOXA-48 gene belonging to clone ST405 in a neonatal unit in southern Spain
Machuca, Jesús; López-Cerero, Lorena; Fernández-Cuenca, Felipe; Gracia-Ahufinger, Irene; Ruiz-Carrascoso, Guillermo; Rodríguez-López, Fernando; Pascual, Álvaro
The dissemination of high-risk clones presents a major challenge for the worldwide health system because of their ability to overcome control measures and cross institutional and national borders and so provide a stable platform for the spread of resistance determinants. Our results showed that K. pneumoniae ST405 can overwhelm single institutions because we found very similar pulsotypes in two different geographically distant hospitals (two or three bands of difference). This clone was not detected in a multicentre Spanish study that characterized the ESBL-producing K. pneumoniae population.14 This raises the question of whether this particularclone was disseminating blaCTX-M-15 before the OXA-48 plasmid capture. Acquisition of the blaOXA-48 gene may be associated with clones already carrying blaCTX-M-15, qnrB and aac(6′)-Ib-cr plasmids, and these determinants may lead to the spread of the clone
Embargado hasta 01/01/2100
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